AKR1A1

Across TCGA patient cohorts, AKR1A1 mutation is significantly associated with the RNA expression of many other genes, with 358 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKR1A1-associated genes across cancer lineages are RN7SL341P, RNVU1-28, and RPL7AP49. Each is linked with AKR1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKR1A1-to-partner and partner-to-AKR1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL341P grouped by AKR1A1-low versus AKR1A1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1A1→partner) and Y-score (partner→AKR1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RN7SL341P →	+0.183	+4.990	<.001	.009	3	2
SKCM	RNVU1-28 →	+0.207	+2.711	.001	.005	3	2
SKCM	RPL7AP49 →	+0.120	+3.188	<.001	<.001	3	1
SKCM	DEFB108F →	+0.052	+3.993	.006	.008	3	1
SKCM	RNU6-3P →	+0.299	+3.155	.002	<.001	3	1
SKCM	SNORD116-16 →	+0.532	+2.915	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 358 associations by consensus.

RN7SL341P by AKR1A1 expression — LUAD

Explore this box plot interactively →