AKNA

Across TCGA patient cohorts, AKNA mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKNA-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and JNK_pT183_Y185. Each is linked with AKNA in more than 6 cancer types. Because this analysis shows association rather than direction, both AKNA-to-partner and partner-to-AKNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by AKNA-low versus AKNA-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKNA→partner) and Y-score (partner→AKNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caspase-7-cleavedD198 →	+1.409	+3.000	<.001	.036	3	7
UCEC	PCNA →	+0.258	+2.459	<.001	<.001	3	4
UCEC	JNK_pT183_Y185 →	-0.204	-2.057	<.001	.001	3	3
UCEC	Cyclin-B1 →	+0.736	+2.459	<.001	<.001	2	4
SKCM	STAT3_pY705 →	-0.261	-2.321	.018	.006	3	3
BLCA	ERK2 →	+0.257	+3.017	.004	.019	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by AKNA expression — STAD

Explore this box plot interactively →