AKNA

Across TCGA pan-cancer cohorts, AKNA RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated AKNA data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher AKNA RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated AKNA expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and BLCA are the cancer types where AKNA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.763	0.629	<.001	142	view →
LUAD	OS	Tertile	II,III,IV	0.736	0.416	<.001	90	view →
BLCA	DFS	Tertile	All	0.693	0.498	<.001	83	view →
UCEC	DFS	Median	All	0.686	0.599	.002	78	view →
SKCM	OS	Quartile	II,III,IV	0.932	0.713	.003	71	view →
KIRP	DFS	Tertile	III,IV	0.131	0.809	.005	61	view →
KICH	OS	Median	III,IV	0.468	1.000	.001	41	view →
CESC	OS	Tertile	All	0.941	0.798	.001	26	view →
SCLC	DFS	Quartile	II,III,IV	0.601	0.187	.003	25	view →
STAD	OS	Quartile	III,IV	0.731	0.444	.004	19	view →
KIRC	OS	Quartile	All	0.552	0.713	.022	12	view →
READ	OS	Tertile	II,III,IV	0.851	0.463	.032	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

AKNA–HNSC (DFS)

Open the HNSC breakdown →