AKNA

Across TCGA cell cohorts, AKNA mutation is significantly associated with the RNA expression of many other genes, with 232 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AKNA-associated genes across cancer lineages are TRPM2, GALNTL5, and PRSS58. Each is linked with AKNA in more than 1 cancer types. Because this analysis shows association rather than direction, both AKNA-to-partner and partner-to-AKNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRPM2 grouped by AKNA-low versus AKNA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKNA→partner) and Y-score (partner→AKNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRPM2 →	+1.650	+3.502	.005	.001	3	2
LUNG_NSCLC_LUAD	GALNTL5 →	+0.032	+2.637	.001	.007	3	2
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
BLOOD_Leukemia	R3HDML →	+0.008	+3.762	<.001	.007	3	1
BLOOD_Leukemia	PRH2 →	+0.142	+3.517	<.001	.005	3	1
BLOOD_Leukemia	SLC25A31 →	+0.030	+2.967	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 232 associations by consensus.

TRPM2 by AKNA expression — LARGE_INTESTINE

Explore this box plot interactively →