AKAP8

Across TCGA patient cohorts, AKAP8 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,644 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AKAP8-associated proteins across cancer lineages are BRD4, SUGP1, and WIZ. Each is linked with AKAP8 in more than 6 cancer types. Because this analysis shows association rather than direction, both AKAP8-to-partner and partner-to-AKAP8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AKAP8 versus BRD4 in OV, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP8→partner) and Y-score (partner→AKAP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	BRD4 →	+0.397	+0.660	<.001	<.001	3	7
GBM	SUGP1 →	+0.205	+0.222	<.001	<.001	3	6
GBM	WIZ →	+0.320	+0.337	<.001	<.001	3	6
LSCC	AQR →	+0.245	+0.469	<.001	<.001	3	5
GBM	BUB3 →	+0.269	+0.375	<.001	<.001	3	5
LSCC	PRCC →	+0.362	+0.567	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,644 associations by consensus.

AKAP8 vs BRD4 — OV

Explore this scatter interactively →