AKAP8

Across TCGA pan-cancer cohorts, AKAP8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of AKAP8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where AKAP8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AKAP8 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where AKAP8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AKAP8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.857	<.001	11	view →
HNSC	Male	III,IV	+0.641	<.001	11	view →
THCA	Male	II,III,IV	−0.680	<.001	10	view →
COAD	Female	All	+0.596	<.001	10	view →
LIHC	Female	II,III,IV	+1.225	<.001	9	view →
STAD	Male	II,III,IV	+0.849	<.001	9	view →
CHOL	Male	All	+1.995	<.001	5	view →
KICH	All	All	−0.724	<.001	4	view →
LUSC	Male	II,III,IV	+0.381	.002	4	view →
ESCA	All	All	+0.649	.003	2	view →
READ	All	All	+0.384	.042	1	view →
KIRP	Male	All	−0.335	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

AKAP8–KIRC

Open the KIRC breakdown →