AKAP8

Across TCGA patient cohorts, AKAP8 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKAP8-associated genes across cancer lineages are FOXO3a_pS318_S321, Caspase-7-cleavedD198, and eEF2. Each is linked with AKAP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKAP8-to-partner and partner-to-AKAP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by AKAP8-low versus AKAP8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP8→partner) and Y-score (partner→AKAP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.154	-2.321	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.452	+1.604	.034	.041	3	2
UCEC	eEF2 →	+0.447	+3.807	<.001	<.001	3	1
UCEC	EGFR_pY1068 →	-0.289	-2.807	.001	.002	3	1
UCEC	eIF4E →	+0.213	+3.472	.005	.002	3	1
UCEC	A-Raf_pS299 →	-0.161	-2.222	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

FOXO3a_pS318_S321 by AKAP8 expression — UCEC

Explore this box plot interactively →