AKAP8

Across TCGA cell cohorts, AKAP8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,982 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible AKAP8-associated GO terms across cancer lineages are Mitotic chromosome condensation, Regulation of chromatin organization, and U2-type prespliceosome assembly. Each is linked with AKAP8 in more than 16 cancer types. Because this analysis shows association rather than direction, both AKAP8-to-partner and partner-to-AKAP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic chromosome condensation grouped by AKAP8-low versus AKAP8-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP8→partner) and Y-score (partner→AKAP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Mitotic chromosome condensation →	+0.187	+1.008	<.001	<.001	3	17
OVARY	Regulation of chromatin organization →	+0.073	+0.560	.004	.002	3	16
BONE	U2-type prespliceosome assembly →	+0.110	+0.839	<.001	<.001	3	16
STOMACH	Positive regulation of T-helper 17 cell lineage commitment →	+0.229	+0.753	<.001	.001	3	16
SOFT_TISSUE	Chromosome condensation →	+0.156	+1.038	.001	<.001	3	16
LARGE_INTESTINE	Negative regulation of transcription initiation by RNA polymerase II →	+0.145	+0.755	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,982 associations by consensus.

Mitotic chromosome condensation by AKAP8 expression — SOFT_TISSUE

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