AKAP8

Across TCGA cell cohorts, AKAP8 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AKAP8-associated genes across cancer lineages are WDR87, F11, and IGSF21. Each is linked with AKAP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKAP8-to-partner and partner-to-AKAP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR87 grouped by AKAP8-low versus AKAP8-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP8→partner) and Y-score (partner→AKAP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	WDR87 →	+0.035	+4.132	.006	.003	3	2
BLOOD_Leukemia	F11 →	+0.117	+3.855	<.001	.007	3	2
BLOOD_Lymphoma	IGSF21 →	+0.100	+3.843	<.001	.007	3	1
BLOOD_Lymphoma	FSHB →	+0.010	+4.662	<.001	.003	3	1
BLOOD_Lymphoma	WFDC13 →	+0.130	+3.927	<.001	.004	3	1
BLOOD_Lymphoma	OR56A3 →	+0.343	+3.523	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

WDR87 by AKAP8 expression — BLOOD_Lymphoma

Explore this box plot interactively →