AKAP7

Across TCGA patient cohorts, AKAP7 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKAP7-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and ERK2. Each is linked with AKAP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKAP7-to-partner and partner-to-AKAP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by AKAP7-low versus AKAP7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP7→partner) and Y-score (partner→AKAP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.288	-2.247	.001	.001	3	1
UCEC	A-Raf_pS299 →	-0.096	-3.459	.028	.005	3	1
UCEC	ERK2 →	+0.162	+2.247	.022	.001	3	1
UCEC	MEK1 →	+0.295	+2.584	.028	.010	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.339	-1.834	.040	.008	3	1
UCEC	p70-S6K_pT389 →	-0.190	-2.700	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

EGFR_pY1068 by AKAP7 expression — UCEC

Explore this box plot interactively →