AKAP7

Across TCGA cell cohorts, AKAP7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,346 significant associations in total. BONE shows the largest number of these associations.

The most reproducible AKAP7-associated GO terms across cancer lineages are Regulation of chromosome segregation, Regulation of mitotic metaphase/anaphase transition, and Regulation of sister chromatid segregation. Each is linked with AKAP7 in more than 10 cancer types. Because this analysis shows association rather than direction, both AKAP7-to-partner and partner-to-AKAP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chromosome segregation grouped by AKAP7-low versus AKAP7-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP7→partner) and Y-score (partner→AKAP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of chromosome segregation →	+0.104	+0.617	.002	.003	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of mitotic metaphase/anaphase transition →	+0.111	+0.589	.005	.009	2	11
UPPER_AERODIGESTIVE_TRACT	Regulation of sister chromatid segregation →	+0.109	+0.686	.004	.005	2	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mitotic nuclear division →	+0.132	+0.634	.002	<.001	3	10
PANCREAS	Negative regulation of mitotic sister chromatid separation →	+0.148	+0.943	<.001	<.001	3	10
PANCREAS	Negative regulation of sister chromatid segregation →	+0.148	+0.943	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,346 associations by consensus.

Regulation of chromosome segregation by AKAP7 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →