AKAP6

Across TCGA patient cohorts, AKAP6 mutation is significantly associated with the RNA expression of many other genes, with 6,047 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKAP6-associated genes across cancer lineages are C18orf54, EXO1, and GINS2. Each is linked with AKAP6 in more than 4 cancer types. Because this analysis shows association rather than direction, both AKAP6-to-partner and partner-to-AKAP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C18orf54 grouped by AKAP6-low versus AKAP6-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP6→partner) and Y-score (partner→AKAP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	C18orf54 →	+0.518	+2.608	<.001	.005	3	5
LUAD	EXO1 →	+0.788	+3.596	.001	.001	3	5
UCEC	GINS2 →	+0.673	+1.727	<.001	<.001	3	5
COAD	ATP5F1B →	+0.324	+1.847	.003	.008	3	5
LUAD	ASF1B →	+0.737	+2.718	.001	.003	3	5
UCEC	SMC2 →	+0.468	+1.095	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,047 associations by consensus.

C18orf54 by AKAP6 expression — LUAD

Explore this box plot interactively →