AKAP4

Across TCGA cell cohorts, AKAP4 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible AKAP4-associated genes across cancer lineages are TAFA4, OR52N5, and DPPA5. Each is linked with AKAP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKAP4-to-partner and partner-to-AKAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAFA4 grouped by AKAP4-low versus AKAP4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP4→partner) and Y-score (partner→AKAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TAFA4 →	+0.151	+4.196	<.001	.002	3	1
LARGE_INTESTINE	OR52N5 →	+0.054	+4.437	<.001	.004	3	1
LUNG_NSCLC_LUAD	DPPA5 →	+0.081	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	C1orf141 →	+0.023	+4.371	.003	.005	3	1
SKIN	UNC93A →	+0.079	+3.263	<.001	.006	3	1
SKIN	NXPH2 →	+0.788	+3.611	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

TAFA4 by AKAP4 expression — LARGE_INTESTINE

Explore this box plot interactively →