AKAP3

Across TCGA patient cohorts, AKAP3 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,410 significant associations in total. GBM shows the largest number of these associations.

The most reproducible AKAP3-associated proteins across cancer lineages are SMCHD1, ZNF609_S1313, and AGFG2. Each is linked with AKAP3 in more than 3 cancer types. Because this analysis shows association rather than direction, both AKAP3-to-partner and partner-to-AKAP3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AKAP3 versus SMCHD1 in BRCA, with a Pearson correlation of 0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP3→partner) and Y-score (partner→AKAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SMCHD1 →	+0.364	+0.515	<.001	<.001	3	4
OV	ZNF609_S1313 →	+0.518	+1.068	.001	.005	3	3
GBM	AGFG2 →	+0.384	+0.453	.001	.004	3	3
LSCC	FOSL2_S200 →	-0.361	-0.561	.005	.001	3	3
GBM	LARP4_S583 →	-0.355	-0.451	<.001	.004	3	3
OV	C2CD5_S305 →	+0.987	+1.493	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,410 associations by consensus.

AKAP3 vs SMCHD1 — BRCA

Explore this scatter interactively →