AKAP3

Across TCGA pan-cancer cohorts, AKAP3 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of AKAP3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where AKAP3 RNA is repressed in tumor relative to normal tissue. In most cancer types AKAP3 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KICH are the cancer types where AKAP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AKAP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.451	<.001	12	view →
THCA	Male	III,IV	−1.415	<.001	11	view →
KICH	Male	All	−1.898	<.001	10	view →
LUAD	All	II,III,IV	−0.463	<.001	7	view →
KIRP	Male	All	−0.871	<.001	6	view →
BRCA	All	III,IV	−0.634	<.001	6	view →
LIHC	All	II,III,IV	−0.257	.002	4	view →
HNSC	Male	All	−0.249	.017	3	view →
COAD	Female	All	−0.324	.013	2	view →
LUSC	Male	All	−0.306	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

AKAP3–KIRC

Open the KIRC breakdown →