AKAP3

Across TCGA patient cohorts, AKAP3 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKAP3-associated genes across cancer lineages are S6_pS235_S236, p38-MAPK_pT180_Y182, and PDK1_pS241. Each is linked with AKAP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both AKAP3-to-partner and partner-to-AKAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS235_S236 grouped by AKAP3-low versus AKAP3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP3→partner) and Y-score (partner→AKAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	S6_pS235_S236 →	-0.395	-3.321	.014	.009	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.349	-1.276	.015	.023	3	3
SKCM	PDK1_pS241 →	-0.171	-2.807	.006	.003	3	2
UCEC	14-3-3_beta →	-0.084	-2.295	.008	.005	3	2
UCEC	ACC1 →	+0.255	+2.335	.028	.018	3	2
UCEC	mTOR_pS2448 →	-0.132	-1.828	.005	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

S6_pS235_S236 by AKAP3 expression — SKCM

Explore this box plot interactively →