AKAP3

Across TCGA cell cohorts, AKAP3 mutation is significantly associated with the RNA expression of many other genes, with 264 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AKAP3-associated genes across cancer lineages are CLVS2, SPIC, and MYOZ2. Each is linked with AKAP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKAP3-to-partner and partner-to-AKAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLVS2 grouped by AKAP3-low versus AKAP3-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP3→partner) and Y-score (partner→AKAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CLVS2 →	+0.043	+4.017	.003	.007	3	1
OESOPHAGUS	SPIC →	+0.040	+4.017	<.001	.007	3	1
OESOPHAGUS	MYOZ2 →	+0.176	+4.392	.002	.003	3	1
OESOPHAGUS	HTR3D →	+0.035	+4.857	<.001	<.001	3	1
BREAST	PROK2 →	+0.110	+3.807	<.001	.006	3	1
BREAST	USP17L8 →	+0.004	+4.196	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 264 associations by consensus.

CLVS2 by AKAP3 expression — OESOPHAGUS

Explore this box plot interactively →