AKAP3

Across TCGA cell cohorts, AKAP3 mutation is significantly associated with the mutation status of many other genes, with 2,731 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AKAP3-associated genes across cancer lineages are KLHL26, KDM2A, and PACS2. Each is linked with AKAP3 in more than 4 cancer types. Because this analysis shows association rather than direction, both AKAP3-to-partner and partner-to-AKAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL26 grouped by AKAP3-low versus AKAP3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP3→partner) and Y-score (partner→AKAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KLHL26 →	+5.584	+5.014	.003	.003	1	5
OVARY	KDM2A →	+3.684	+3.217	.006	.006	1	5
SKIN	PACS2 →	+3.532	+3.357	.005	.005	1	5
LARGE_INTESTINE	EXOSC10 →	+2.510	+2.047	.004	.004	1	5
SKIN	HRH3 →	+5.117	+3.977	.001	.001	1	4
BLOOD_Leukemia	FBXO24 →	+4.000	+5.050	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,731 associations by consensus.

KLHL26 by AKAP3 expression — BLOOD_Lymphoma

Explore this box plot interactively →