AKAP11

Across TCGA patient cohorts, AKAP11 protein abundance is significantly associated with the RNA expression of many other genes, with 10,466 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AKAP11-associated genes across cancer lineages are PIK3R6, CRTAM, and SH2B3. Each is linked with AKAP11 in more than 4 cancer types. Because this analysis shows association rather than direction, both AKAP11-to-partner and partner-to-AKAP11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AKAP11 versus PIK3R6 in LSCC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP11→partner) and Y-score (partner→AKAP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PIK3R6 →	+0.606	+0.194	<.001	.004	3	5
LUAD	CRTAM →	+0.742	+0.155	<.001	.009	3	4
GBM	SH2B3 →	+0.561	+0.216	<.001	<.001	3	4
UCEC	CYTIP →	+0.761	+0.212	.003	.006	3	4
LSCC	ARHGAP9 →	+0.743	+0.249	<.001	<.001	3	4
GBM	GYPC →	+0.572	+0.132	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,466 associations by consensus.

AKAP11 vs PIK3R6 — LSCC

Explore this scatter interactively →