AKAP11

Across TCGA cell cohorts, AKAP11 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,533 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible AKAP11-associated GO terms across cancer lineages are Negative regulation of hematopoietic stem cell differentiation, Peptidyl-serine phosphorylation, and Phosphatidylinositol biosynthetic process. Each is linked with AKAP11 in more than 13 cancer types. Because this analysis shows association rather than direction, both AKAP11-to-partner and partner-to-AKAP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of hematopoietic stem cell differentiation grouped by AKAP11-low versus AKAP11-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP11→partner) and Y-score (partner→AKAP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of hematopoietic stem cell differentiation →	+0.177	+0.935	<.001	<.001	3	14
STOMACH	Peptidyl-serine phosphorylation →	+0.068	+0.586	.008	.006	3	14
UPPER_AERODIGESTIVE_TRACT	Phosphatidylinositol biosynthetic process →	+0.079	+1.144	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.071	+0.837	<.001	<.001	3	14
SKIN	Golgi vesicle transport →	+0.065	+0.757	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Intra-Golgi vesicle-mediated transport →	+0.097	+0.924	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,533 associations by consensus.

Negative regulation of hematopoietic stem cell differentiation by AKAP11 expression — LUNG_SCLC

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