AKAP11

Across TCGA cell cohorts, AKAP11 mutation is significantly associated with the RNA expression of many other genes, with 932 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AKAP11-associated genes across cancer lineages are SMIM23, SEL1L2, and PBOV1. Each is linked with AKAP11 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKAP11-to-partner and partner-to-AKAP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM23 grouped by AKAP11-low versus AKAP11-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP11→partner) and Y-score (partner→AKAP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SMIM23 →	+0.637	+4.887	<.001	.009	3	2
BLOOD_Lymphoma	SEL1L2 →	+0.011	+4.643	.004	.005	3	2
BLOOD_Lymphoma	PBOV1 →	+0.019	+5.169	<.001	.001	3	2
UPPER_AERODIGESTIVE_TRACT	RBMXL2 →	+0.073	+3.857	.001	.004	3	2
CNS	FGF4 →	+0.006	+4.472	<.001	.004	3	2
STOMACH	RNASE8 →	+0.079	+3.044	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 932 associations by consensus.

SMIM23 by AKAP11 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →