AKAP10

Across TCGA pan-cancer cohorts, AKAP10 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated AKAP10 data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher AKAP10 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AKAP10 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where AKAP10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	1.000	0.765	.005	37	view →
PDAC	DFS	Median	IV	0.245	0.766	.017	9	view →
HNSC	DFS	Median	II,III,IV	0.995	0.897	.006	7	view →
LUAD	DFS	Quartile	III,IV	0.559	0.993	.040	4	view →
LSCC	OS	Median	II,III,IV	0.810	1.000	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

AKAP10–CCRCC (DFS)

Open the CCRCC breakdown →