AKAP10

Across TCGA pan-cancer cohorts, AKAP10 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of AKAP10’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AKAP10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AKAP10 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and KICH are the cancer types where AKAP10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AKAP10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.656	<.001	11	view →
THCA	Male	All	−0.735	<.001	9	view →
KICH	Female	II,III,IV	−1.168	<.001	7	view →
KIRC	All	All	+0.326	<.001	7	view →
LIHC	All	All	+0.417	<.001	6	view →
CHOL	Female	All	+1.993	<.001	5	view →
KIRP	All	All	+0.333	.011	4	view →
UCEC	All	All	−0.803	<.001	2	view →
BLCA	All	All	+0.475	.036	2	view →
LUSC	Female	III,IV	−0.594	.018	1	view →
READ	All	All	−0.435	.024	1	view →
LUAD	Female	II,III,IV	−0.388	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

AKAP10–HNSC

Open the HNSC breakdown →