AKAP10

Across TCGA patient cohorts, AKAP10 mutation is significantly associated with the RNA expression of many other genes, with 1,684 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKAP10-associated genes across cancer lineages are MIR3908, RNU6-440P, and RAP1BP3. Each is linked with AKAP10 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKAP10-to-partner and partner-to-AKAP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3908 grouped by AKAP10-low versus AKAP10-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP10→partner) and Y-score (partner→AKAP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR3908 →	+0.251	+4.970	<.001	.005	3	2
COAD	RNU6-440P →	+0.331	+7.153	<.001	<.001	3	2
SKCM	RAP1BP3 →	+0.079	+4.531	.006	.005	3	2
UCEC	YTHDF3-AS1 →	+0.651	+2.556	<.001	.001	3	1
UCEC	CCL5 →	+1.429	+3.823	<.001	<.001	3	1
UCEC	LINC02084 →	+0.558	+2.617	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,684 associations by consensus.

MIR3908 by AKAP10 expression — SKCM

Explore this box plot interactively →