AKAP10

Across TCGA patient cohorts, AKAP10 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKAP10-associated genes across cancer lineages are Annexin-1, eIF4E, and A-Raf_pS299. Each is linked with AKAP10 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKAP10-to-partner and partner-to-AKAP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by AKAP10-low versus AKAP10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP10→partner) and Y-score (partner→AKAP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.729	+2.604	<.001	.005	3	2
UCEC	eIF4E →	+0.218	+3.335	.012	.005	3	1
UCEC	A-Raf_pS299 →	-0.197	-3.584	<.001	.002	3	1
UCEC	ERK2 →	+0.212	+2.459	.007	.019	3	1
UCEC	FoxM1 →	+0.321	+3.000	.002	.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.149	-3.797	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Annexin-1 by AKAP10 expression — UCEC

Explore this box plot interactively →