AKAP10

Across TCGA cell cohorts, AKAP10 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,780 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AKAP10-associated GO terms across cancer lineages are Positive regulation of DNA-templated transcription initiation, Regulation of telomere maintenance, and Positive regulation of transcription initiation by RNA polymerase II. Each is linked with AKAP10 in more than 17 cancer types. Because this analysis shows association rather than direction, both AKAP10-to-partner and partner-to-AKAP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA-templated transcription initiation grouped by AKAP10-low versus AKAP10-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP10→partner) and Y-score (partner→AKAP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of DNA-templated transcription initiation →	+0.092	+0.835	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Regulation of telomere maintenance →	+0.076	+0.989	<.001	<.001	3	18
LUNG_SCLC	Positive regulation of transcription initiation by RNA polymerase II →	+0.090	+0.810	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Regulation of telomere capping →	+0.148	+0.908	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of telomere capping →	+0.128	+0.833	<.001	<.001	3	16
LUNG_SCLC	Regulation of telomere maintenance via telomerase →	+0.089	+0.927	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,780 associations by consensus.

Positive regulation of DNA-templated transcription initiation by AKAP10 expression — LUNG_SCLC

Explore this box plot interactively →