AK5

Across TCGA patient cohorts, AK5 mutation is significantly associated with the RNA expression of many other genes, with 5,324 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AK5-associated genes across cancer lineages are ZWINT, VTI1A, and BUB3. Each is linked with AK5 in more than 3 cancer types. Because this analysis shows association rather than direction, both AK5-to-partner and partner-to-AK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWINT grouped by AK5-low versus AK5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AK5→partner) and Y-score (partner→AK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZWINT →	+0.875	+1.947	<.001	<.001	3	4
UCEC	VTI1A →	+0.341	+2.243	<.001	<.001	3	3
UCEC	BUB3 →	+0.546	+1.947	<.001	<.001	3	3
SKCM	MELK →	+0.858	+2.328	<.001	.003	3	3
UCEC	ABRAXAS2 →	+0.334	+2.209	.003	.001	3	3
UCEC	ZMYND19 →	+0.505	+2.568	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,324 associations by consensus.

ZWINT by AK5 expression — UCEC

Explore this box plot interactively →