AK5

Across TCGA pan-cancer cohorts, AK5 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated AK5 data layer compared with 6 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher AK5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated AK5 expression acts as an unfavorable survival marker, although some lineages such as SCLC and COAD show a favorable association.

UVM, STAD, and SARC are the cancer types where AK5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.411	0.732	<.001	119	view →
STAD	DFS	Quartile	All	0.398	0.638	<.001	92	view →
SARC	DFS	Median	All	0.531	0.683	<.001	42	view →
OV	DFS	Tertile	II,III,IV	0.475	0.587	.007	38	view →
KIRP	OS	Quartile	II,III,IV	0.573	0.920	.003	33	view →
MESO	OS	Median	All	0.435	0.646	.003	29	view →
SCLC	DFS	Quartile	II,III,IV	0.639	0.197	.006	28	view →
COAD	OS	Tertile	IV	1.000	0.267	.003	21	view →
THCA	DFS	Median	II,III,IV	0.879	0.413	.009	15	view →
ACC	DFS	Tertile	IV	0.659	0.151	.024	14	view →
KIRC	DFS	Tertile	IV	0.745	0.455	.027	9	view →
LIHC	OS	Tertile	III,IV	0.869	0.457	.004	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

AK5–UVM (DFS)

Open the UVM breakdown →