AK5

Across TCGA patient cohorts, AK5 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AK5-associated genes across cancer lineages are ACC_pS79, JNK2, and p27_pT157. Each is linked with AK5 in more than 2 cancer types. Because this analysis shows association rather than direction, both AK5-to-partner and partner-to-AK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by AK5-low versus AK5-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AK5→partner) and Y-score (partner→AK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	ACC_pS79 →	+0.367	+2.331	.019	.019	3	2
UCEC	JNK2 →	+0.240	+2.727	<.001	.002	3	2
LUSC	p27_pT157 →	+0.107	+2.834	.007	.034	3	2
SKCM	p90 RSK →	+0.311	+2.321	.002	.035	2	3
UCEC	PCNA →	+0.252	+2.137	<.001	.001	3	2
SKCM	eIF4G →	+0.389	+3.000	.049	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

ACC_pS79 by AK5 expression — LUSC

Explore this box plot interactively →