AK5

Across TCGA cell cohorts, AK5 mutation is significantly associated with the RNA expression of many other genes, with 439 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AK5-associated genes across cancer lineages are GPR152, FAM25C, and CBY1. Each is linked with AK5 in more than 1 cancer types. Because this analysis shows association rather than direction, both AK5-to-partner and partner-to-AK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR152 grouped by AK5-low versus AK5-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AK5→partner) and Y-score (partner→AK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GPR152 →	+0.048	+3.347	<.001	.005	3	1
SKIN	FAM25C →	+0.551	+3.345	.001	.007	3	1
LARGE_INTESTINE	CBY1 →	+0.674	+3.160	<.001	.006	3	1
LARGE_INTESTINE	FZD3 →	+0.841	+3.364	<.001	.002	3	1
LARGE_INTESTINE	CCNP →	+1.373	+3.364	<.001	.002	3	1
LARGE_INTESTINE	C2CD5 →	+0.564	+3.364	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 439 associations by consensus.

GPR152 by AK5 expression — SKIN

Explore this box plot interactively →