AJUBA

Across TCGA cell cohorts, AJUBA mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible AJUBA-associated genes across cancer lineages are R3HDML, VWC2L, and SERPINB11. Each is linked with AJUBA in more than 1 cancer types. Because this analysis shows association rather than direction, both AJUBA-to-partner and partner-to-AJUBA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, R3HDML grouped by AJUBA-low versus AJUBA-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AJUBA→partner) and Y-score (partner→AJUBA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	R3HDML →	+0.013	+4.569	<.001	.003	3	1
BLOOD_Leukemia	VWC2L →	+0.009	+3.339	<.001	.006	3	1
BLOOD_Leukemia	SERPINB11 →	+0.021	+3.289	<.001	.009	3	1
BLOOD_Leukemia	TSSK1B →	+0.012	+3.289	<.001	.009	3	1
CNS	FSHB →	+0.032	+5.321	<.001	.005	3	1
LARGE_INTESTINE	IL25 →	+0.075	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

R3HDML by AJUBA expression — BLOOD_Leukemia

Explore this box plot interactively →