AIRE

Across TCGA pan-cancer cohorts, AIRE Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated AIRE data layer compared with 21 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher AIRE Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated AIRE expression acts as an unfavorable survival marker.

HNSC, STAD, and GBM are the cancer types where AIRE Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.051	0.743	<.001	42	view →
STAD	OS	Median	III,IV	0.003	0.633	<.001	12	view →
GBM	OS	Median	All	0.089	0.413	.023	6	view →
LUSC	OS	Median	II,III,IV	0.201	0.616	.018	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

AIRE–HNSC (OS)

Open the HNSC breakdown →