AIRE

Across TCGA pan-cancer cohorts, AIRE RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of AIRE’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where AIRE RNA is repressed in tumor relative to normal tissue. In most cancer types AIRE is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, CHOL, and KIRP are the cancer types where AIRE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AIRE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.118	<.001	10	view →
CHOL	All	II,III,IV	+0.120	.006	4	view →
KIRP	All	III,IV	−0.076	<.001	4	view →
COAD	All	All	+0.161	.038	1	view →
LIHC	Female	All	+0.038	.034	1	view →
LUAD	All	All	+0.037	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

AIRE–KICH

Open the KICH breakdown →