AIRE

Across TCGA patient cohorts, AIRE RNA expression is significantly associated with the protein abundance of many other proteins, with 7,392 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible AIRE-associated proteins across cancer lineages are CDKN2C, CELF2, and MS4A1. Each is linked with AIRE in more than 2 cancer types. Because this analysis shows association rather than direction, both AIRE-to-partner and partner-to-AIRE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AIRE versus CDKN2C in PDAC, with a Pearson correlation of 0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AIRE→partner) and Y-score (partner→AIRE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CDKN2C →	+0.378	+0.189	<.001	<.001	3	3
LSCC	CELF2 →	+0.587	+0.212	<.001	<.001	3	3
LSCC	MS4A1 →	+1.157	+0.123	<.001	<.001	3	3
COAD	SRA1 →	-0.268	-0.353	.002	.003	3	3
PDAC	NES_S680 →	+0.743	+0.138	<.001	<.001	3	3
LUAD	PPP1R21 →	+0.163	+0.072	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,392 associations by consensus.

AIRE vs CDKN2C — PDAC

Explore this scatter interactively →