AIRE

Across TCGA patient cohorts, AIRE mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AIRE-associated genes across cancer lineages are MSH2, MSH6, and PCNA. Each is linked with AIRE in more than 1 cancer types. Because this analysis shows association rather than direction, both AIRE-to-partner and partner-to-AIRE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by AIRE-low versus AIRE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIRE→partner) and Y-score (partner→AIRE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.346	-2.973	<.001	.035	3	1
UCEC	MSH6 →	-0.528	-2.459	<.001	.018	3	1
UCEC	PCNA →	+0.195	+2.000	.045	.032	3	1
UCEC	Rab25 →	-0.351	-3.169	.019	.019	3	1
UCEC	Annexin-1 →	+0.759	+2.341	.001	.019	3	1
UCEC	TIGAR →	+0.150	+2.727	.029	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MSH2 by AIRE expression — UCEC

Explore this box plot interactively →