AIRE

Across TCGA cell cohorts, AIRE RNA expression is significantly associated with the protein abundance of many other proteins, with 331 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible AIRE-associated proteins across cancer lineages are METAP1, GRB2, and PTMA. Each is linked with AIRE in more than 3 cancer types. Because this analysis shows association rather than direction, both AIRE-to-partner and partner-to-AIRE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AIRE versus METAP1 in OVARY, with a Pearson correlation of -0.55.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AIRE→partner) and Y-score (partner→AIRE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	METAP1 →	-0.819	-0.017	.002	.001	3	4
OVARY	GRB2 →	-1.048	-0.021	.005	.005	3	4
OVARY	PTMA →	-1.438	-0.026	.007	.003	3	4
OVARY	RPS29 →	-1.071	-0.017	.003	.001	3	4
OVARY	TBCB →	-1.079	-0.020	.001	.008	3	3
OVARY	RPS19 →	-1.250	-0.023	<.001	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 331 associations by consensus.

AIRE vs METAP1 — OVARY

Explore this scatter interactively →