AIRE

Across TCGA cell cohorts, AIRE mutation is significantly associated with the drug of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AIRE-associated genes across cancer lineages are Alisertib, Niraparib, and Ruxolitinib. Each is linked with AIRE in more than 1 cancer types. Because this analysis shows association rather than direction, both AIRE-to-partner and partner-to-AIRE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Alisertib grouped by AIRE-low versus AIRE-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIRE→partner) and Y-score (partner→AIRE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Alisertib →	+0.793	+2.646	.028	.047	3	1
LARGE_INTESTINE	Niraparib →	+0.519	+2.678	.002	.037	3	1
LARGE_INTESTINE	Ruxolitinib →	+0.318	+2.646	.038	.047	3	1
LARGE_INTESTINE	Luminespib →	+0.672	+2.646	.027	.047	3	1
LARGE_INTESTINE	GSK2801 →	+0.441	+2.649	.004	.046	3	1
LARGE_INTESTINE	OSI-027 →	+0.519	+2.678	.016	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Alisertib by AIRE expression — LARGE_INTESTINE

Explore this box plot interactively →