AIP

Across TCGA patient cohorts, AIP mutation is significantly associated with the RNA expression of many other genes, with 173 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible AIP-associated genes across cancer lineages are RNU6-147P, HERC2P11, and RNY1P1. Each is linked with AIP in more than 1 cancer types. Because this analysis shows association rather than direction, both AIP-to-partner and partner-to-AIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-147P grouped by AIP-low versus AIP-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIP→partner) and Y-score (partner→AIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-147P →	+0.411	+5.812	<.001	.003	3	2
SKCM	HERC2P11 →	+0.053	+3.408	<.001	.002	3	2
UCEC	RNY1P1 →	+0.496	+4.750	<.001	.005	3	2
UCEC	RNU6-1013P →	+0.321	+5.137	.002	.003	3	2
STAD	RNA5SP65 →	+0.848	+4.520	<.001	.005	3	2
STAD	IGLVVI-22-1 →	+0.164	+5.070	.006	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 173 associations by consensus.

RNU6-147P by AIP expression — CESC

Explore this box plot interactively →