AIMP2

Across TCGA patient cohorts, AIMP2 mutation is significantly associated with the RNA expression of many other genes, with 343 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AIMP2-associated genes across cancer lineages are RNU1-112P, OR1F2P, and OR51A1P. Each is linked with AIMP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AIMP2-to-partner and partner-to-AIMP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-112P grouped by AIMP2-low versus AIMP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIMP2→partner) and Y-score (partner→AIMP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU1-112P →	+0.189	+2.216	.002	.007	3	2
COAD	OR1F2P →	+0.218	+4.237	<.001	.008	3	2
COAD	OR51A1P →	+0.111	+6.142	<.001	<.001	3	1
SKCM	RNU6-999P →	+0.271	+5.080	<.001	.004	3	1
SKCM	MIR4667 →	+0.248	+4.680	<.001	.007	3	1
UCEC	LINC01607 →	-0.644	-3.443	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 343 associations by consensus.

RNU1-112P by AIMP2 expression — UCEC

Explore this box plot interactively →