AIMP1

Across TCGA patient cohorts, AIMP1 mutation is significantly associated with the RNA expression of many other genes, with 594 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AIMP1-associated genes across cancer lineages are TRAJ24, RNU6-552P, and SNORD31B. Each is linked with AIMP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AIMP1-to-partner and partner-to-AIMP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ24 grouped by AIMP1-low versus AIMP1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIMP1→partner) and Y-score (partner→AIMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	TRAJ24 →	+0.894	+4.187	<.001	.009	3	2
BLCA	RNU6-552P →	+0.387	+5.106	<.001	.008	3	1
BLCA	SNORD31B →	+0.640	+6.147	<.001	.002	3	1
UCEC	YTHDF3-AS1 →	+0.849	+3.754	<.001	<.001	3	1
UCEC	ZNHIT3 →	+0.479	+3.245	.006	.008	3	1
UCEC	TRBV11-3 →	+0.414	+2.171	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 594 associations by consensus.

TRAJ24 by AIMP1 expression — LUSC

Explore this box plot interactively →