AIMP1

Across TCGA pan-cancer cohorts, AIMP1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of AIMP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AIMP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AIMP1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and STAD are the cancer types where AIMP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AIMP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.399	<.001	12	view →
LIHC	Male	II,III,IV	+1.304	<.001	9	view →
STAD	All	All	+0.493	<.001	6	view →
THCA	Male	III,IV	−0.329	.003	6	view →
CHOL	Female	All	+2.166	<.001	5	view →
KICH	All	All	−0.683	<.001	5	view →
LUAD	Male	All	+0.367	<.001	5	view →
UCEC	All	All	−0.467	.006	4	view →
BRCA	All	II,III,IV	+0.229	<.001	4	view →
COAD	Male	All	+0.335	.004	3	view →
ESCA	Female	All	+0.773	.045	2	view →
LUSC	Male	All	+0.259	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

AIMP1–HNSC

Open the HNSC breakdown →