AIMP1

Across TCGA patient cohorts, AIMP1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AIMP1-associated genes across cancer lineages are ERK2, MEK1, and PDCD4. Each is linked with AIMP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AIMP1-to-partner and partner-to-AIMP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by AIMP1-low versus AIMP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIMP1→partner) and Y-score (partner→AIMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.238	+2.999	.014	.035	3	1
UCEC	MEK1 →	+0.401	+2.321	.029	.035	3	1
UCEC	PDCD4 →	-0.686	-2.321	.003	.035	3	1
UCEC	STAT3_pY705 →	-0.514	-3.311	<.001	.010	3	1
UCEC	XBP1 →	-0.164	-2.986	.021	.035	3	1
UCEC	Bax →	+0.258	+2.321	.032	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

ERK2 by AIMP1 expression — UCEC

Explore this box plot interactively →