AIM2

Across TCGA patient cohorts, AIM2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,680 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AIM2-associated genes across cancer lineages are SAMD9L, HLA-F, and PSMB8-AS1. Each is linked with AIM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both AIM2-to-partner and partner-to-AIM2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AIM2 versus SAMD9L in LSCC, with a Pearson correlation of 0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIM2→partner) and Y-score (partner→AIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SAMD9L →	+1.022	+1.240	<.001	<.001	3	3
LSCC	HLA-F →	+1.403	+1.668	<.001	<.001	3	3
LSCC	PSMB8-AS1 →	+0.842	+1.489	<.001	<.001	3	2
LSCC	SMTNL1 →	+1.256	+1.228	<.001	.004	3	2
LSCC	HLA-B →	+0.877	+1.050	<.001	.002	3	2
LUAD	USP30-AS1 →	+0.608	+1.171	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,680 associations by consensus.

AIM2 vs SAMD9L — LSCC

Explore this scatter interactively →