Across TCGA cell cohorts, AIFM3 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AIFM3-associated genes across cancer lineages are PRND, OR2M5, and OR11L1. Each is linked with AIFM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AIFM3-to-partner and partner-to-AIFM3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIFM3→partner) and Y-score (partner→AIFM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRND →	+0.019	+3.141	.006	.002	3	2
CNS	OR2M5 →	+0.030	+4.321	<.001	.009	3	1
CNS	OR11L1 →	+0.026	+5.566	<.001	<.001	3	1
CNS	KIR2DS4 →	+0.028	+4.643	<.001	.003	3	1
BLOOD_Lymphoma	WFDC8 →	+0.018	+4.867	<.001	.009	3	1
LARGE_INTESTINE	TKTL2 →	+0.037	+3.187	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

AIFM3 survival (RNA) · tumor vs normal (RNA) · all AIFM3 data types