AIFM2

Across TCGA cell cohorts, AIFM2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AIFM2-associated genes across cancer lineages are DCAF12L1, ITGAD, and SPIC. Each is linked with AIFM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AIFM2-to-partner and partner-to-AIFM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCAF12L1 grouped by AIFM2-low versus AIFM2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIFM2→partner) and Y-score (partner→AIFM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DCAF12L1 →	+0.012	+4.867	<.001	.009	3	1
LARGE_INTESTINE	ITGAD →	+0.015	+5.095	<.001	<.001	3	1
LARGE_INTESTINE	SPIC →	+0.172	+2.925	<.001	.007	3	1
LARGE_INTESTINE	LCE1D →	+0.247	+3.217	<.001	.006	3	1
LARGE_INTESTINE	SAMD7 →	+0.016	+4.141	<.001	<.001	3	1
LARGE_INTESTINE	IFIT1B →	+0.030	+4.408	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

DCAF12L1 by AIFM2 expression — BLOOD_Lymphoma

Explore this box plot interactively →