Across TCGA patient cohorts, AIF1 RNA expression is significantly associated with the protein abundance of many other proteins, with 23,791 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AIF1-associated proteins across cancer lineages are ARHGAP45, ARHGAP9, and PLCB2. Each is linked with AIF1 in more than 9 cancer types. Because this analysis shows association rather than direction, both AIF1-to-partner and partner-to-AIF1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AIF1→partner) and Y-score (partner→AIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGAP45 →	+0.687	+1.082	<.001	<.001	3	10
GBM	ARHGAP9 →	+0.646	+1.170	<.001	<.001	3	10
GBM	PLCB2 →	+0.754	+1.331	<.001	<.001	3	10
UCEC	PLEKHO2 →	+0.620	+1.598	<.001	<.001	3	10
UCEC	PLEKHO2_T311 →	+0.666	+1.291	<.001	<.001	3	10
LSCC	ARHGEF6_S684 →	+0.897	+0.740	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,791 associations by consensus.

Exploration

AIF1 survival (RNA) · tumor vs normal (RNA) · all AIF1 data types