Across TCGA pan-cancer cohorts, AIF1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of AIF1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where AIF1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AIF1 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.
KIRC, THCA, and COAD are the cancer types where AIF1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AIF1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.