Across TCGA patient cohorts, AIF1 protein abundance is significantly associated with the RNA expression of many other genes, with 18,503 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AIF1-associated genes across cancer lineages are CYTH4, MFNG, and APOBEC3H. Each is linked with AIF1 in more than 9 cancer types. Because this analysis shows association rather than direction, both AIF1-to-partner and partner-to-AIF1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIF1→partner) and Y-score (partner→AIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CYTH4 →	+1.246	+1.033	<.001	<.001	3	10
UCEC	MFNG →	+0.813	+0.735	<.001	<.001	3	10
HNSC	APOBEC3H →	+0.788	+0.583	<.001	<.001	3	10
GBM	NCF4 →	+1.320	+1.097	<.001	<.001	3	10
GBM	CSF2RB →	+1.221	+1.040	<.001	<.001	3	10
BRCA	IL2RB →	+1.024	+0.593	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,503 associations by consensus.

Exploration

AIF1 survival (RNA) · tumor vs normal (RNA) · all AIF1 data types