Across TCGA patient cohorts, AIF1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AIF1-associated genes across cancer lineages are MEK1, VHL, and TFRC. Each is linked with AIF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AIF1-to-partner and partner-to-AIF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AIF1→partner) and Y-score (partner→AIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.524	+3.000	.013	.037	3	1
UCEC	VHL →	-1.484	-3.000	<.001	.036	3	1
SKCM	TFRC →	+0.673	+3.000	.026	.035	2	2
SKCM	Caveolin-1 →	-0.792	-3.169	.018	.019	3	1
UCEC	A-Raf_pS299 →	-0.163	-3.000	.018	.037	1	2
UCEC	Rab25 →	-0.916	-3.000	<.001	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

AIF1 survival (RNA) · tumor vs normal (RNA) · all AIF1 data types