Across TCGA cell cohorts, AIF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,310 significant associations in total. BONE shows the largest number of these associations.

The most reproducible AIF1-associated GO terms across cancer lineages are Positive regulation of proteasomal protein catabolic process, Regulation of proteasomal protein catabolic process, and Neutrophil-mediated killing of fungus. Each is linked with AIF1 in more than 5 cancer types. Because this analysis shows association rather than direction, both AIF1-to-partner and partner-to-AIF1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AIF1→partner) and Y-score (partner→AIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Positive regulation of proteasomal protein catabolic process →	+0.083	+0.270	.004	.001	3	5
OESOPHAGUS	Regulation of proteasomal protein catabolic process →	+0.078	+0.192	<.001	.005	3	5
BLOOD_Leukemia	Neutrophil-mediated killing of fungus →	+0.878	+1.808	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.054	+0.135	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of GTPase activity →	+0.040	+0.120	.001	.002	3	5
LARGE_INTESTINE	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.049	+0.247	.002	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,310 associations by consensus.

Exploration

AIF1 survival (RNA) · tumor vs normal (RNA) · all AIF1 data types